
Alcohol use disorder (AUD) is a medical condition characterised by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD encompasses conditions previously referred to as alcohol abuse, alcohol dependence, alcohol addiction, and
| Characteristics | Values |
|---|---|
| Diagnosis | Alcohol Use Disorder (AUD) |
| Other Names | Alcohol abuse, alcohol dependence, alcohol addiction, alcoholism |
| Cause | Genetic and environmental factors |
| Risk Factors | Family history, psychiatric disorders, trauma, stress, anxiety, social and cultural influences |
| Symptoms | Craving alcohol, hangovers, withdrawal symptoms, impaired immune response, liver cirrhosis, increased cancer risk, trouble sleeping, shakiness, restlessness, nausea, sweating, seizures, hallucinations, delirium tremens, high blood pressure, heart disease, stroke, nutritional deficiencies, peptic ulcers, sexual dysfunction, violent behaviour, etc. |
| Diagnosis Method | Patient history, questionnaires, physical examination, mental status exam, laboratory tests |
| Treatment | Medication (naltrexone, acamprosate, disulfiram), behavioural therapy, mutual-support groups, alcohol counselling, mindfulness-based therapies |
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What You'll Learn

Alcohol withdrawal symptoms
Withdrawal symptoms typically begin within six to 24 hours of stopping or significantly reducing heavy, long-term alcohol use. Mild symptoms include headache, mild anxiety, insomnia, upset stomach, nervousness, irritability, excessive sweating, and increased blood pressure. These symptoms can begin to appear as soon as six to 12 hours after the last drink.
More severe symptoms can develop within 12 to 48 hours after the last drink and may include hallucinations, seizures, and delirium tremens (DTs). DTs are a serious and potentially fatal complication of alcohol withdrawal, affecting about 1%-1.5% of people with alcohol withdrawal. They typically occur between 24 to 72 hours after the last drink and can continue for several days, with the most intense symptoms appearing around four to five days after the last drink.
Prolonged withdrawal symptoms such as insomnia and mood changes can last for weeks or even months after the last drink. The severity and duration of alcohol withdrawal vary based on several factors, including the amount and frequency of alcohol consumption, as well as individual differences.
It is important to seek medical attention if experiencing any concerning symptoms of alcohol withdrawal. Treatment options for alcohol withdrawal and AUD include medication, behavioural therapy, mutual-support groups, and short-term medications to lessen symptoms.
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Increased cancer risk
Alcohol is a chemical carcinogen, and heavy, long-term consumption increases the risk of developing cancer. The International Agency for Research on Cancer (IARC) classified alcohol as a Group 1 carcinogen in 1987, due to sufficient evidence of its causal relationship with cancers of the oral cavity, pharynx, larynx, oesophagus, and liver. Epidemiological studies have consistently shown that alcohol drinkers have a higher risk of certain cancers than non-drinkers, and that this risk increases with the amount of alcohol consumed.
Alcohol consumption increases the risk of melanoma and pancreatic, prostate, stomach, breast, and colorectal cancers. It is also linked to a higher incidence of head and neck cancers in individuals with a specific genetic makeup who can tolerate the adverse effects of acetaldehyde, a toxic chemical formed during ethanol metabolism, and continue to drink moderate amounts of alcohol. However, it is important to note that the association between alcohol consumption and certain other cancers, such as bladder, ovarian, and uterine cancers, is inconsistent or non-existent.
The mechanisms by which alcohol increases cancer risk are multifaceted. Firstly, alcohol can damage DNA, the cell's "instruction manual," leading to uncontrolled cell growth and cancer development. Secondly, it increases the levels of hormones like estrogen, which is implicated in breast cancer. Thirdly, alcohol enhances the absorption of carcinogens, making it easier for oral cells to be exposed to harmful chemicals, especially when used in conjunction with tobacco.
The link between alcohol consumption and cancer is significant, with approximately 538,000 alcohol-associated cancer cases in the United States in 2022, resulting in about 20,000 deaths. These statistics highlight the importance of reducing alcohol intake to mitigate cancer risk. The recommended limits for alcohol consumption in the US Dietary Guidelines are currently under reconsideration to reflect the increased cancer risk associated with even moderate drinking.
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Liver cirrhosis
There are several causes of liver cirrhosis, one of which is long-term alcohol abuse. Alcohol-associated liver disease occurs when excessive alcohol consumption damages the liver and its function. Other causes include inherited liver diseases, long-term use of certain medications, high doses of vitamin A, and chronic heart failure with liver congestion. Some people with cirrhosis may have multiple causes of liver damage, while for others, the cause may be unknown.
The symptoms of liver cirrhosis may not appear until the liver is severely damaged. However, some possible symptoms include internal bleeding due to the bursting of enlarged veins in the esophagus, stomach, or intestines, known as varices, swelling in the lower legs, ankles, or feet (edema), and swelling of the abdomen due to fluid buildup (ascites).
Treatment for liver cirrhosis aims to slow or stop further damage. Lifestyle changes, medications, and liver transplantation are potential treatment options. Eliminating alcohol is crucial for those with alcohol-related liver cirrhosis. Vaccinations can prevent viral hepatitis, a potential cause of cirrhosis. Early treatment for conditions that cause blood buildup or prevent blood flow to the liver can also help prevent cirrhosis.
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Cognitive issues
Alcoholism, or alcohol use disorder (AUD), is a medical condition characterised by a diminished ability to control alcohol consumption despite adverse social, occupational, or health consequences. AUD can be mild, moderate, or severe, and is considered a brain disorder. Cognitive issues are a key feature of AUD, and these can manifest in various ways and with varying severity.
Cognitive impairments in people with AUD are associated with problems in acquiring, storing, retrieving, and using knowledge. These impairments can be understood as deficits in mental activities that involve the handling of information, such as memory and learning processes. Research has found a correlation between the extent of alcohol consumption and cognitive performance, with greater consumption linked to poorer performance on cognitive tasks. However, the relationship is complex, and not all individuals with AUD exhibit obvious cognitive impairments.
The specific cognitive deficits associated with AUD can vary and may be related to childhood behavioural problems, such as conduct disorder, attention deficit hyperactivity disorder (ADHD), learning disabilities, or hyperactivity. Additionally, premorbid disorders such as antisocial personality traits or a family history of alcoholism may also contribute to cognitive impairments. While the exact mechanisms are not fully understood, it is believed that prolonged alcohol ingestion impairs normal brain functioning, leading to these cognitive deficits.
One of the well-known cognitive issues associated with alcoholism is alcohol-related brain damage (ARBD). ARBD can manifest in different forms, such as Wernicke-Korsakoff syndrome, which is linked to low levels of thiamine (vitamin B1). Individuals with ARBD may experience a decline in memory and thinking skills, impacting their ability to perform tasks independently. However, ARBD does not always progress like other forms of dementia, and recovery is possible with abstinence from alcohol and appropriate support.
The cognitive issues associated with alcoholism can also be understood through theoretical models. Cognitive models, for example, explain alcohol abuse in terms of "automatic thoughts," which are underlying beliefs and assumptions that influence an individual's feelings and behaviours related to alcohol. These automatic thoughts can contribute to the development and maintenance of AUD by providing a sense of justification or rationalisation for continued alcohol use.
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Co-occurring mental health disorders
Alcohol use disorder (AUD) is a medical condition characterised by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is often accompanied by co-occurring mental health disorders, and vice versa. The presence of these co-occurring disorders can present significant challenges to an individual's well-being and ability to function.
The co-occurrence of AUD and mental health disorders can be understood through several mechanisms. Firstly, pre-existing psychiatric disorders may increase the likelihood of developing AUD, as alcohol is often used as a coping mechanism to manage the symptoms of these disorders. However, alcohol use can exacerbate the underlying problems and contribute to a vicious cycle. Secondly, alcohol use, particularly during adolescence and long-term exposure, can increase the risk of developing psychiatric disorders. Alcohol use can induce brain changes that heighten the risk of other mental disorders, and the reverse is also true, where mental disorders can alter brain chemistry to make substances like alcohol feel more rewarding.
The most common mental health conditions that co-occur with AUD include depressive disorders, anxiety disorders, trauma- and stress-related disorders, other substance use disorders, and sleep disorders. Bipolar disorder, attention-deficit hyperactivity disorder (ADHD), and psychotic disorders such as schizophrenia also frequently co-occur with AUD. These co-occurring disorders can influence each other, regardless of which developed first, and left untreated, can lead to a worsening of symptoms or increased substance misuse.
Genetics and family history also play a significant role in the development of AUD and co-occurring mental health disorders. Heritability accounts for approximately 60% of the risk, and parental drinking patterns can influence the likelihood of their children developing AUD. Additionally, environmental factors such as trauma and adverse childhood experiences further contribute to the risk of developing both AUD and mental health disorders.
The treatment of AUD and co-occurring mental health disorders requires an integrated approach that addresses the symptoms of both conditions simultaneously. This typically involves a combination of behavioural therapies, mutual-support groups, and medications. The likelihood of successful recovery is higher when both conditions are treated together, and evidence-based treatments can help individuals achieve positive health outcomes and live healthier, more fulfilling lives.
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Frequently asked questions
AUD, commonly known as alcoholism, is a medical condition characterised by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. It is considered a brain disorder and can be mild, moderate, or severe.
AUD can cause physical symptoms such as cirrhosis of the liver, pancreatitis, epilepsy, polyneuropathy, alcoholic dementia, heart disease, nutritional deficiencies, peptic ulcers, sexual dysfunction, irregular heartbeat, impaired immune response, and severe withdrawal symptoms if stopped suddenly.
AUD treatment may include medication and behavioural therapy. Three medications approved by the U.S. Food and Drug Administration to help reduce drinking and prevent relapse are naltrexone, acamprosate, and disulfiram. Behavioural treatments include brief interventions, reinforcement approaches, mindfulness-based therapies, and mutual-support groups.





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