
Opana, also known as oxymorphone, is a highly addictive opioid medication that can be administered orally or intravenously. While it is typically prescribed for pain management, it has a high potential for abuse and can lead to serious side effects, including respiratory depression and neonatal withdrawal syndrome. Due to these risks, it is crucial to take Opana exactly as directed by a doctor and to be aware of potential drug interactions, especially with central nervous system (CNS) depressants such as alcohol. When taken with alcohol or other CNS depressants, the effects of Opana may be amplified, leading to dangerous consequences. Therefore, it is imperative to exercise caution and refrain from consuming alcohol or other drugs during Opana treatment to mitigate the risk of adverse events.
| Characteristics | Values |
|---|---|
| Opana ER dosage | 20mg |
| Extraction method | Isopropyl alcohol |
| Isopropyl alcohol concentration | 91% |
| Equipment | Micron filter, hose clamp, 1cc (100 unit), 29 gauge insulin syringes |
| Process | Remove coating, grind up Opana ER, boil down solution |
| Precautions | Ensure equipment is sterile, do not attempt IV without expertise |
What You'll Learn

Use 91% isopropyl alcohol
It is important to note that injecting any kind of pill is not safe. Isopropyl alcohol contains more toxic substances than pure ethanol. It is recommended to use isopropyl exclusively to clean utensils and not for performing extractions.
If you plan to use the extracted oxymorphone intravenously, remember that it is as much as 10 times more potent than when taken orally and about 3-4 times as potent when insufflated. Make sure all your equipment is completely sterile and always use a micron filter if available.
Only 91% isopropyl alcohol will work for this extraction as anything weaker will cause the solution to gel. 91% isopropyl alcohol is very flammable, so take care when using a heat source.
- Use a hose clamp to grind up 1/3 of a 30mg Opana ER tablet after removing the coating.
- Draw up the oxymorphone/rubbing alcohol solution using a third syringe with the needle removed, and carefully squirt it into the back of a second syringe (with the cotton in it).
- If there is room left in the syringe, add more alcohol to the spoon to get as much of the ground Opana into the second syringe as possible.
- Thoroughly wash and dry the spoon and turn on a stovetop to low heat. Insert the plunger into the second syringe and carefully push the solution through the cotton and needle into the clean spoon.
- You should have a clear solution in the spoon. Place the spoon on the stovetop on the lowest possible setting.
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Grind the Opana ER
To perform an alcohol extraction on Opana 20mg, you must first grind the Opana ER. This can be done using a dremel tool, which can grind the pill to dust. Another method is to use a hose clamp to grind up the Opana ER. However, this method may not work on newer versions of the pill.
One user describes their method:
> "I used a hose clamp to grind up 1/3 of a 30mg Opana ER after removing the coating. Note: If you plan to use the extracted oxymorphone intravenously, please remember that it is as much as 10 times more potent than when taken orally, and about 3-4 times as potent as when insufflated."
Another user describes their method of grinding Opana ER:
> "I literally just use a dremel and a bowl of pot and it works perfect."
Other methods of grinding Opana ER include using a file or something like a pedegg, which will also contain the dust.
It is important to note that grinding Opana ER can be dangerous and may not be effective, as it remains an extended-release drug even when ground up. Injecting or smoking Opana is also extremely dangerous and can be life-threatening.
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Use a micron filter
Micron filters are an important component of the alcohol extraction process for Opana 20mg. They help ensure the safety and quality of the final product by removing impurities and contaminants.
A micron is a unit of measurement that describes the pore size of a filter. Micron filters are designed to trap and remove dirt, debris, and even microscopic particles from the liquid being filtered. The pore size of a micron filter determines its ability to remove contaminants. The smaller the micron rating, the finer the particles it can capture. For example, a 5-micron filter can remove particles as small as 5 microns, while a 1-micron filter can capture smaller particles.
When performing alcohol extraction for Opana 20mg, it is recommended to use a micron filter to ensure the purity and safety of the product. The specific micron rating you choose will depend on the type of contaminants you want to remove and the desired level of filtration. For instance, if you're primarily concerned with removing yeast, a 5-micron filter may suffice, but for clearer results, a 1-micron filter is recommended.
There are various types of micron filters available, such as bag filters, cartridge filters, and sheet filters. Bag filters are popular in larger facilities due to their high flow rate capabilities, with porosities ranging from 200 microns to 1 micron. Cartridge filters, on the other hand, are commonly used for depth filtration and offer a closed, sanitary, and fume-free environment. Sheet filters have the disadvantage of being labour-intensive in terms of setup, tear-down, and cleaning, and they may require a ventilation system to minimise exposure to volatile organic compounds.
When selecting a micron filter for alcohol extraction of Opana 20mg, it is important to consider the specific requirements of your process. Factors such as batch size, the nature of contaminants, and desired level of filtration will influence your choice of micron rating and filter type. Remember to prioritise safety and sterility throughout the extraction process.
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Sterilise equipment
Sterilising equipment is an important step in the process of alcohol extraction. It is crucial to ensure that all equipment is completely sterile to avoid contamination and potential health risks. Here are the detailed steps and instructions for sterilising equipment:
Firstly, it is important to clean the equipment before sterilisation. Any residue or contaminants left on the equipment can hinder the effectiveness of the sterilisation process. There are specialised enzymatic detergent solutions available for soaking instruments. These detergents are designed to effectively remove any contaminants and are often provided with specific instructions for their use. It is important to follow these instructions carefully. In addition, disassembling equipment with multiple parts can aid in thorough cleaning, ensuring that all components are properly sanitised.
After cleaning, the equipment should be dried to remove any moisture. This is particularly important if the equipment has intricate or delicate parts that are sensitive to moisture. Proper drying helps prevent the growth of microorganisms and ensures the effectiveness of the sterilisation process.
Once the equipment is clean and dry, there are several methods available for sterilisation. One common method is the use of Ethylene Oxide (EtO), which is suitable for heat-sensitive and moisture-sensitive items. EtO is a colourless gas that effectively kills all microorganisms, providing reliable sterilisation. This method is often used for medical devices with plastic or electrical components that cannot withstand high temperatures.
Another method is steam sterilisation, which involves the use of steam and heat to eliminate microorganisms. This process should be monitored regularly with commercial spore preparations to ensure its effectiveness. Steam sterilisation is often used for medical devices and can be monitored using G. stearothermophilus spores incubated at 55-60°C.
Additionally, low-temperature sterilisation methods are available, such as vaporised hydrogen peroxide or peracetic acid. These methods are effective alternatives for items that may be sensitive to high temperatures or certain chemicals.
Regardless of the chosen sterilisation method, it is imperative to follow the recommended guidelines and procedures. Proper sterilisation techniques help ensure the safety of the process and protect against potential health hazards.
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Boil the solution
Boiling the solution is a crucial step in the alcohol extraction process for Opana 20mg. This step involves heating the mixture to evaporate the solvent and concentrate the solute, which, in this case, is the desired opioid.
Firstly, ensure that you are using a suitable heating apparatus, such as a hot plate or a Bunsen burner, that can provide a consistent and controlled heat source. Place the container with the solution on the heat source and adjust the temperature to a level that will allow the solvent to boil gently. A gentle boil is preferable to a vigorous one as it helps prevent excessive splashing or rapid evaporation, which could result in the loss of the solute or solvent.
During the boiling process, it is essential to maintain constant agitation or stirring of the solution. This ensures even heating and prevents localised boiling, which could lead to uneven evaporation and potential burning or scorching of the solute. Use a heat-resistant glass rod or a stirring apparatus that can withstand the temperature.
The duration of the boiling step will depend on the volume of the solution and the solvent being used. In the case of isopropyl alcohol, for example, it is crucial to use a concentration of at least 91% to avoid a high water content that could cause gelling. The boiling process should continue until the majority of the solvent has evaporated, leaving behind a more concentrated solution or residue containing the desired opioid.
It is important to note that boiling the solution may not completely remove all traces of the solvent. Depending on the solvent used, some residue may remain, and additional steps may be required to purify the final product. Always refer to specific guidelines and safety precautions when handling opioids and solvents to ensure a safe and effective extraction process.
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Frequently asked questions
91% isopropyl alcohol is considered the best option for Opana 20mg extraction. Weaker alcohol will not work as the water content is too high and will cause the solution to gel.
You will need a micron filter, a hose clamp, and 1cc (100 unit), 29 gauge insulin syringes. All equipment must be sterile.
First, remove the coating from the tablet. Then, use the hose clamp to grind up 1/3 of a 30mg Opana ER tablet.
Alcohol extraction of Opana 20mg tablets can be dangerous. The medication is intended to be swallowed whole and should not be dissolved. Alcohol extraction may lead to rapid release of the medication, which can be fatal. Additionally, combining Opana with alcohol can cause serious side effects such as slow/shallow breathing, severe drowsiness/dizziness, and unusual lightheadedness.

